Huan Wang

Lecturer

Email: huanweiol@sina.com

Education & Positions

Hebei Medical University, B.S., 1996 - 2000.

Stony Brook University, USA Ph.D., 2001 - 2007.

Stony Brook University, USA postdoc., 2007 - 2009.

Hebei Medical University, Lecturer, 2016 - .

Research Interests

The doctoral program focuses on the mechanism of cataract formation. We believe that oxidative environment and increased calcium concentration are the most important factors leading to cataract. Recent research direction is drug metabolism enzyme research. The main research concerns the vasomotor activity of diphenylflurazine metabolites. By comparing the effects of diphenylflurazine and its metabolites on hyperk /5-HT preconstriction vessels, we want to explore whether they have vasomotor metabolites, which is of great significance to ensure the safety and effectiveness of clinical medication. 

Publications

（1）Yan Wang, Jia Yuan, Dongfang Dai, Junli Liu, Jing Xu, Huan Wang, Chaoming Mao, Yichuan Xiao.Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1.July 2018Acta Biochimica et Biophysica Sinica 50(9)

（2）Wang H, Gao J, Sun X, Martinez-Wittinghan FJ, Li L, Varadaraj K, Farrell M, Reddy VN, White TW, Mathias RT. The Effects of GPX-1 Knockout on Membrane Transport and Intracellular Homeostasis in the Lens. J Membr Biol. 2009 Jan;227(1):25-37

（3）Mathias RT#, Wang H. Local osmosis and isotonic transport. J Membr Biol. 2005 Nov; 208(1):39-53 (#:PI) (Cited 12 times) White TW#, Wang H, Mui R, Litteral J, Brink PR. Cloning and functional expression of invertebrate connexins from Halocynthia pyriformis. FEBS Lett. 2004 Nov 5;577(1-2):42-8 (#:PI) 

（4）McNulty R, Wang H, Mathias RT, Ortwerth BJ, Truscott RJ, Bassnett S. Regulation of tissue oxygen levels in the mammalian lens. J Physiol. 2004 Sep 15;559(Pt 3):883-98. Epub 2004 Jul 22.  

（5）Das S, Wang H, Molina SA, Martinez-Wittinghan FJ, Jena S, Bossmann LK, Miller KA, Mathias RT, Takemoto DJ. PKCγ, role in lens differentiation and gap junction coupling. Curr Eye Res. 2011 Jul;36(7):620-31. 

（6）Shi Y, De Maria AB, Wang H, Mathias RT, FitzGerald PG, Bassnett S. Further analysis of the lens phenotype in Lim2-deficient mice. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7332-9 

（7）Fudge DS, McCuaig JV, Van Stralen S, Hess JF, Wang H, Mathias RT, FitzGerald PG. Intermediate filaments regulate tissue size and stiffness in the murine lens. Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3860-7. 

（8）Gao J1, Wang H, Sun X, Varadaraj K, Li L, White TW, Mathias RT. The effects of age on lens transport. Invest Ophthalmol Vis Sci. 2013 Nov 1;54(12):7174-87. doi: 10.1167/iovs.13-12593.