Fan Zhang, 

Associate Professor, Supervisor of Doctorate Candidates, Supervisor of Master's Candidates

Hebei Province Key Laboratory of Innovative Drug Research and Evaluation 

Department of Biochemistry and Molecular Biology 

Hebei Medical University. 

050017, Shijiazhuang, Hebei, CHINA

E-mail: zhangfan86@126.com  zhangfan86@hebmu.edu.cn

Work and Education Experience

2015.11- Now  Associate Professor, Department of Biochemistry and Molecular Biology, Hebei Medical University

2013.7- 2015.10  Lecturer, Department of Biochemistry and Molecular Biology, Hebei Medical University

2007.9- 2013.7   PH.D. Degree of Pharmocolgy, Hebei Medical University                       

2003.9- 2007.7   Bachelor Degree of Pharmaceutics, Hebei Medical University

Research interests:

1.The effects of ion channels and molecular mechanisms underlying neuropsychiatric diseases.

2.Screening of ion channel modulators.

Representative Publications in Recent 5 Years:

1. Fan Zhang, Yiying Wang, Yu Liu, Hao Han, Dandan Zhang, Xizhenzi Fan, Xiaona Du, Nikita Gamper, Hailin Zhang. Transcriptional regulation of voltage-gated sodium channels contributes to GM-CSF-induced pain. The Journal of Neuroscience, 2019.  (IF 6.07)

2. Fan Zhang, Yani Liu, Feng Tang, Bo Liang, Huanming Chen, Hailin Zhang, Kewei Wang. Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for anti-epilepsy. The FASEB Journal, 2019.  (IF 5.59)

3. Fan Zhang, Sylvain Gigout, Yu Liu, Yiying Wang, Han Hao, Noel J. Buckley, Hailin Zhang, Ian C. Wood, Nikita Gamper. Repressor element 1-silencing transcription factor drives the development of chronic pain states. Pain, 2019. (IF 6.03)

4. Fan Zhang, Yi Mi, Jinlong Qi, Junwei Li, Man Si, Bingcai Guan, Xiaona Guan, Hailong An, Hailin Zhang. Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol, 168, 1030-1042, 2013.  (IF 6.8)

5. Fan Zhang, Shuna Liu, Lu Jin, LiangQinDaoErJi TANG, Xu Zhao, Tianshuo Yang, Yiyue Wang, Binghui Huo, Ruiyu Liu, Han Li. Antinociceptive efficacy of retigabine and flupirtine for gout arthritis pain. 2020, Pharmacology, Accepted.（IF 1.67）

6. Fan Zhang, Yani Liu, Dandan Zhang, Xizhenzi Fan, Decheng Shao, Han Li. Suppression of KCNQ/M potassium channel in dorsal root ganglia neurons contributes to the development of osteoarthritic pain. Pharmacology 2019. （IF 1.67）

7. Fan Zhang, Yanxin Cheng, Hong Li, Qingzhong Jia, Hailin Zhang, Senming Zhao. Inhibition of Kv7/M channel currents by the local anesthetic chloroprocaine. Pharmacology, 2015, 96, 124-130. （IF 1.67）

8. Jinlong Qi, Fan Zhang＃(Co-first author), Yi Mi, Yan Fu, Wen Xu, Diqun Zhang, Yibing Wu, Xiaona Du, Qingzhong Jia, Kewei Wang, Hailin Zhang. Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin -7(4H)-ones as novel Kv7/KCNQ potassium channel activators. European Journal of Medicinal Chemistry, 2011, 46(3), 934-943.  ( IF:3.3)