Haixia Gao

Professor, Supervisor of Doctorate Candidates, Supervisor of Master's Candidates

Hebei Medical University. 

050017, Shijiazhuang, Hebei, CHINA

E-mail: gaohx686@yahoo.com

Work and Education Experience

1990.9-1994.6    Shandong University, Bachelor degree

2001.9-2004.5    Hebei Medical University, Master degree

2008.9-2012.5     Hebei Medical University, PhD 

2014.1-2017.12    University of Leeds, UK, Research fellowship,

1994.6-hitherto    Work in Hebei Medical University.

Research interests

We interested in the function and regulation of ion channels with a particular focus to the regulation of cellular excitability. We try to develop a mechanistic understanding of neuronal communication and how these mechanisms are affected in various neurological diseases, such as stroke and epilepsy. Example of specific current projects include: i) Regulation of M-type K+ channels by oxidants and zinc; ii) Neuroprotective role of M channels in epilepsy and stroke.

Representative Publications in Recent 5 Years

1.Gao H, Boillat A, Huang D, Liang C, Peers C, Gamper N.Intracellular zinc activates KCNQ   channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate.Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6410-E6419. doi: 10.1073/pnas.1620598114. Epub 2017 Jul 17.

2.Gao H, Chen X, Du X, Guan B, Liu Y, Zhang H. EGF enhances the migration of cancer cells by up-regulation of TRPM7. Cell Calcium. 2011 Dec;50(6):559-68.

3.Ge Y, Wang Y, Chen P, Wang Y, Hou C, Wu Y, Zhang M, Li L, Huo C, Shi Q, Gao H *.

Polyhydroxytriterpenoids and Phenolic Constituents from Forsythia suspensa (Thunb.) Vahl Leaves. J Agric Food Chem. 2016 Jan 13;64(1):125-31.

4.Du X, Gao H, Jaffe D, Zhang H, Gamper N. M-type K+ channels in peripheral nociceptive pathways. Br J Pharmacol. 2017 Aug 11. doi: 10.1111/bph.13978. [Epub ahead of print] 

5.Huang D, Huang S, Gao H, Liu Y, Qi J, Chen P, Wang C, Scragg JL, Vakurov A, Peers C, Du X, Zhang H, Gamper N. Redox-Dependent Modulation of T-Type Ca(2+) Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P. Antioxid Redox Signal. 2016 Aug 10;25(5):233-51. 

6.Dun J, Chen X, Gao H, Zhang Y, Zhang H, Zhang Y. Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis. Exp Biol Med (Maywood). 2015 Mar 2. 

7.Zhao Z, Cui W, Zhang H, Gao H, Li X, Wang Y, Hu H, Li B.Pre-treatment of a single high-dose of atorvastatin provided cardioprotection in different ischaemia/reperfusion models via activating mitochondrial KATP channel.  Eur J Pharmacol. 2015 Mar 15;751:89-98.