Hailin Zhang, Professor, Supervisor of Doctorate Candidates, Supervisor of Master's Candidates

Dean, School of Basic Medical Science

Director, Research Institute of Medical Science and Health 

Vice president, Hebei Medical University 

050017, Shijiazhuang, Hebei, CHINA

Tel: 86-311-8626-5562； 86-311-86266565

E-mail: zhanghl@hebmu.edu.cn

Education

1991.04-1995.12 London University, St. George’s Medical School, Dept. Pharmacology, Ph.D

1984.09-1987.07 Hebei Medical University, Dept. Pharmacology, MS 

1979.09-1984.07Hebei Medical University, School of Clinical Medicine, BM

Postdoc

1998.06-2000.05Mount Sinai Medical School of NYU, Dept. Physiology and Biophysics

1997.06-1998.06Howard Hughes Medical Institute, Mount Sinai Medical center, New York 

1996.12-1997.06London University, St. George’s Medical School, Dept. Pharmacology

Professional positions

2017.09-Director, Research Institute of Medical Science and Health

2013.01-Vice President, Hebei Medical University,

2010.01-2013.01Dean, School Of Basic Medical Science

2007.01-2018.01Chair, Department Of Pharmacology

2003.01-2010.01Deputy Dean, School of Pharmaceutical Science

2001.10-Professor, Dept. Pharmacology, Hebei Medical University

2000.05-2001.10 Instructor, Dept. Physiology and Biophysics, Mount Sinai Medical School of NYU, Dept. Physiology and Biophysic

1990.09-1991.04Lecture, Dept. Pharmacology, Hebei Medical University, 

1987.09-1990.09Assistant Professor, Dept. Pharmacology, Hebei Medical 

Research interests

Molecular Pharmacology, Neurobiology. Ion channels and signaling regulation of ion channels; Pharmacology of ion channels; Ion channel-related diseases.

Representative Publications in Recent 5 Years

1.Huiran Zhang,Yani Liu, Hongchao Men, Fan Zhang, Hailin Zhang. LRRCA8A and ANO1 contribute to serum-induced VRAC in a Ca 2+-dependent manners. J Pharmacol Sci,2020 Jul;143(3):176-181. 

2.Dong Zhang, Hongchao Men, Ludi Zhang, Xiangxin Gao, Jingjing Wang, Leying Li, Qiaoying Zhu, Hailin Zhang, Zhanfeng Jia. Inhibition of M/K v 7 Currents Contributes to Chloroquine-Induced Itch in Mice. Front Mol Neurosci, 2020 Jun 30;13:105. 

3.Huang D, Shi S, Liang C, Zhang X, Du X, An H, Peers C, Zhang H, Gamper N Delineating an extracellular redox-sensitive module in T-type Ca2+ channels. J Biol Chem. 2020 Mar 18. pii: jbc.RA120.012668. doi: 10.1074/jbc.RA120.012668

4.Su M, Li L, Wang J, Sun H, Zhang L, Zhao C, Xie Y, Gamper N, Du X, Zhang H Kv7.4 Channel Contribute to Projection-Specific Auto-Inhibition of Dopamine Neurons in the Ventral Tegmental Area. Front Cell Neurosci. 2019 Dec 18;13:557..

5.Liu Y, Zhang H, Men H, Du Y, Xiao Z, Zhang F, Huang D, Du X, Gamper N, Zhang H Volume-regulated Cl- current: contributions of distinct Cl- channels and localized Ca2+ signals. Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C466-C480

6.Zhang F, Wang Y, Liu Y, Han H, Zhang D, Fan X, Du X, Gamper N, Zhang H Transcriptional Regulation of Voltage-Gated Sodium Channels Contributes to GM-CSF-Induced Pain. J Neurosci. 2019 Jun 26;39(26):5222-5233.

7.Sun Y, Li L, Liao M, Su M, Wan C, Zhang L, Zhang H. A systematic data acquisition and mining strategy for chemical profiling of Aster tataricus rhizoma (Ziwan) by UHPLC-Q-TOF-MS and the corresponding anti-depressive activity screening. J Pharm Biomed Anal. 2018 May 30;154:216-226.

8.Zhao C, Su M, Wang Y, Li X, Zhang Y, Du X, Zhang H. Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons. Front Cell Neurosci. 2017 Dec 14;11:405. 

9.Li L, Sun H, Ding J, Niu C, Su M, Zhang L, Li Y, Wang C, Gamper N, Du X, Zhang H. Selective targeting of M-type potassium Kv 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour. Br J Pharmacol. 2017 Dec;174(23):4277-4294..

10.Du X, Hao H, Yang Y, Huang S, Wang C, Gigout S, Ramli R, Li X, Jaworska E, Edwards I, Deuchars J, Yanagawa Y, Qi J, Guan B, Jaffe DB, Zhang H, Gamper N. Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission. J Clin Invest. 2017 May 1;127(5):1741-1756.

11.Wang X, Tang H, Wei EQ, Wang Z, Yang J, Yang R, Wang S, Zhang Y, Pitt GS, Zhang H, Wang C. Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. J Mol Cell Cardiol. 2017 Mar;104:63-74. 

12.Huang D，Liang C，Zhang F，Me H，Du X，Gamper N and Zhang H. Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca2+ channels，Biochemical and Biophysical Research Communications，2016.4.29，473(2)：396~402，

13.Zhang X, An H，Li J, Zhang Y, Liu Y, Jia Z, Zhang W, Chu L and Zhang H. Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect. Br J Pharmacol，2016.12.01;173(24)：3480~3491

14.Zhou N, Huang S，Li L，Huang D，Yan Y，Du X and Zhang H. K(v)7/kcnq potassium channel enhances neuronal differentiation of pc12 cells，Neuroscience，2016.10.1，333：356~367

15.Huang D, Huang S，Gao H，Liu Y，Qi J，Chen P，Wang C，Scragg JL.，Vakurov A，Peers C，Du X，Gamper N, Zhang H. Redox-Dependent Modulation of T-Type Ca2+ Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P. Antioxidants & Redox Signaling，2016.8.01;25(5)：233~251

16.Zhang X， Zhang H， Zhou N，Xu J，Si M，Jia Z， Du X，Zhang H. Tannic acid modulates excitability of sensory neurons and nociceptive behavior and the Ionic mechanism，European Journal of Pharmacology，2015.10.5，764：633~642

17.Huang D, Huang S，Peers C，Du X，Gamper N and Zhang H. GABAB receptors inhibit low-voltage activated and high-voltage activated Ca2+ channels in sensory neurons via distinct mechanisms，Biochemical and Biophysical Research Communications，2015.9.18，465(2)：188~193

18.Liu Y，Zhang H，Huang D，Qi J，Xu J，Gao H，Du X，Gamper N and Zhang H. Characterization of the effects of Cl- channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl- channels，Pflugers Archiv-European Journal of Physiology，2015.7.01，467(7)：1417~1430