Ping Lv, Professor of Pharmacology, Supervisor of Doctorate Candidates, Supervisor of Master's Candidates

Department of Pharmacology

Hebei Medical University. 

Shijiazhuang, Hebei, 050017, China

Office: 0311-86266219

E-mail: lping77@hotmail.com

Work and Education Experience

Year      Degree  Institution

1996-2001 BS      Hebei Medical University, China

2001-2004 MS      Hebei Medical University, China

2004-2007 PhD/MD  Hebei Medical University, China

Positions and appointment

2007-2011  Postdoctoral Research Fellow, Lab of Dr. Yamoah, Center for Neuroscience, University of California, Davis CA

2011-2013  Assistant Professor, Department of Pharmacology, 

Hebei Medical University, Shijiazhuang, China

2013-2017  Associate Professor, Department of Pharmacology, 

Hebei Medical University, Shijiazhuang, China

2017-2019  Professor, Department of Pharmacology, Hebei Medical 

University, Shijiazhuang, China

2019-2020  Visiting Scholar, Department of Physiology and Cell biology, University of Nevada, Reno, NV

2020-present Professor, Department of Pharmacology, Hebei Medical University, Shijiazhuang, China

Research interests

Within the field of Sensory Neurophysiology, our group’ specializes in researching and studying conditions related to hearing loss, the most common sensorineural disorder in humans. We study the cochlear structure and its function using different and highly sophisticated techniques, such as electrophysiological techniques, molecular and genetic techniques and imaging techniques. The identification of essential structures, proteins and genes during development stages and in the mature inner ear are the basis to suggest new pharmaceutical targets and development of gene therapy strategies for hearing restoration.

Recently, we focus on how ion channels contribute to normal audition and how disfunction of ion channels in hair cells and auditory afferent neurons lead to hearing loss. Studying the molecular properties of ion channels, will allow us to better understand the pathophysiological mechanisms lying behind progressive deafness.

Representative Publications:

1 Wang S, Geng Q, Huo L, Ma Y, Gao Y, Zhang W, Zhang H, Lv P, Jia Z. Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice. Front Mol Neurosci. 2019 Dec 4;12:296.

2 Shen H, Liu W, Geng Q, Li H, Lu M, Liang P, Zhang B, Yamoah EN, Lv P. Age-dependent up-regulation of HCN channels in spiral ganglion neurons correlates well with hearing loss. Frontiers in Aging Neuroscience 2018 Nov 6; 10:353

3 Shen H, Liang P, Qiu S, Zhang B, Wang Y, Lv P. The role of Na+, K+-ATPase in the hypoxic vasoconstriction in isolated rat basilar artery. Vascul Pharmacol. 2016，Jun 81:53-60.

4 Lv P, Kim HJ, Lee HJ, Sihn CR, Fathabad SG, Mousavi-Nik A Wang W, Doyle JK,  Wang G, Gratton MA, Yamoah EN. Genetic, Cellular and Functional Evidence for Ca2+ Inflow through Cav1.2 and Cav1.3 Channels in Murine Spiral Ganglion Neurons. 2014, J Neurosci May 21, 2014，34(21):7383–7393 

5 Lv P, Sihn CR, Wang W, Shen H, Kim HJ, Rocha-Sanchez SM, Yamoah EN. Posthearing Ca2+ currents and their roles in shaping the different modes of firing of spiral ganglion neurons. 2012, J Neurosci. 14;32(46):16314-30

6 Lv P, Wei D, Yamoah EN. KCNQ-type currents in spiral ganglia neurons involvement in progressive sensorineural hearing loss. 2010 J. Biol Chem 285 34699-707

7 Lv P, Rodriguez-Contreras A, Kim HJ, Zhu J, Wei D, Sihn CR, Eastwood E, Mu K, Levic S, Song H, Petrov Y, Smith PJS, Yamoah EN. Release and elementary mechanisms of nitric oxide in hair cells. 2010. J Neurophysiol. 103(5) 2494-505

8 Zhang XD, Lee JH, Lv P, Chen WC, Kim HJ, Wei D, Wang W, Sihn CR, Doyle KJ, Rock JR, Chiamvimonvat N, Yamoah EN.  Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2575-80 

9 Wang W, Kim HJ, Lv P, Tempel B, Yamoah EN. Association of Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses. J Neurophysiol. 2013 110(8):1751-64

10 Yang J, Bouvron S, Lv P, Chi F, Yamoah EN. Functional features of trans-differentiated hair cells mediated by atoh1 reveals a primordial mechanism. J Neurosci. 2012 Mar 14;32(11):3712-25