Chuan Wang, 

Professor, Supervisor of Doctorate Candidates, Supervisor of Master's Candidates

Deputy Dean of Clinical College of Hebei Medical University, 

050017, Shijiazhuang, Hebei, CHINA

E-mail: wangchuan@hebmu.edu.cn

Work and Education Experience

09/1991 – 07/1996  Hebei Medical University, Clinic Medicine, Bachelor degree

09/1996 – 07/1999  Hebei Medical University, as a teacher of Pharmacology

09/1999 – 07/2002  Hebei Medical University, Pharmacology, Master degree

09/2002 – 07/2005  Hebei Medical University, Pharmacology, Ph.D. degree

07/2005 – 07/2008  Weis Center for Research, Geisinger Clinic, US, Pharmacology, Postdoctoral associate

07/2008 – 07/2011  Duke University, US, Pharmacology, Postdoctoral associate

09/2011 – now  Hebei Medical University, Department of Pharmacology, Professor

Research interests:

Interest in the research on the pathogenesis, clinical transformation and drug treatment of cardiovascular diseases and disorders of the nervous system, such as arrhythmia, heart failure, peripheral neuropathic pain, especially for the ion channel related diseases.

Representative Publications in Recent 5 Years:

1.Yin C, Liu B, Wang P, Li X, Li Y, Zheng X, Tai Y, Wang C*, Liu B. Eucalyptol Alleviates Inflammation and Pain Responses in a Mouse Model of Gout Arthritis. Br J Pharmacol. 2020 May;177(9):2042-2057 (* Corresponding author, IF: 7.73) (SCI二区TOP)

2.X Wang, Q Jia, Y Yu, H Wang, H Guo, X Ma, Ch Liu, X Chen, Q Miao, B Guan, S Su, H Wei, and C Wang*. Inhibition of the I Na/K and the activation of peak I Na contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs，Acta Pharmacologica Sinica (2020) 2020 Aug 3. Online ahead of print (* Corresponding author, IF: 5.064) (SCI二区)

3.Hu Q, Wang Q, Wang C*, Tai Y, Liu B, Shao X, Fang J, Liu B. TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1. Front Pharmacol. 2019 Apr 26;10:453. eCollection (*Corresponding author, IF: 4.225) (SCI二区)

4.Zheng X, Tai Y, He D, Liu B, Wang C, Shao XM, Jordt SE, Liu B. ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: a molecular mechanism of ET-1-induced mechanical hyperalgesia. Mol Pain. 2019 Apr 16:1744806919842473. ( IF: 3.2) (SCI三区)

5.Yang J, Yin HS, Cao YJ, Jiang ZA, Li YJ, Song MC, Wang YF, Wang ZH, Yang R, Jiang YF, Sun JP, Liu BY, Wang C*. Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. Cell Physiol Biochem. 2018;49(2):728-742. (*Corresponding author, IF: 5.5) (SCI二区)

6.Wang X, Tang H, Wei E, Wang Z, Yang J, Yang R, Wang S, Zhang Y, Pitt GS, Zhang H, Wang C*. Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. Journal of Molecular and Cellular Cardiology. 2017 Mar;104:63-74 (*Corresponding author, IF: 5.296) (SCI二区) 

7.Tai Y*, Wang C*, Wang Z, Liang Y, Du J, He D, Fan X, Jordt S, Liu B. Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skinlightening reagent hydroquinone. Scientific Reports 2017 Aug 7: 7532 （* co-first author, IF: 4.122) (SCI二区)

8.Yang J, Zhang L, Wang H, Guo Z, Liu Y, Zhang Y, Wang C*, Li Q. Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats. Stem Cells Int. 2017;2017:5706193. (*Corresponding author, IF: 3.989) (SCI三区)

9.Wei EQ, Sinden DS, Mao L, Zhang H, Wang C, Pitt GS. Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4010-E4019  (IF: 9.504) (SCI二区)

10.Wu J, Wang X, Chung YY, Koh CH, Liu Z, Guo H, Yuan Q, Wang C, Su S, Wei H. L-type calcium channel inhibition contributes to the proarrhythmic effects of aconitine in human cardiomyocytes. PLos One 2017 Jan 5; 12(1): e0168435. (IF: 2.766) (SCI三区)

11.Wang C, Shan B, Wang Q, Xu Q, Zhang H, LeiH. Fusion of Ssm6a with a protein scaffold retains selectivity on Nav1.7 and improves its therapeutic potential against chronic pain. Chem Biol Drug Des. 2017 Jun;89(6):825-833  (IF: 2.328) (SCI四区)

12.Dong Jun-Hong,  Wang Yi-Jing,  Cui Min,  Wang Xiao-Jing,  Zheng Wen-Shuai,  et al Wang Chuan, Yu Xiao,  Sun Jin-Peng Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and beta-Arrestin-1-Regulated Lactate Metabolism. BIOLOGICAL PSYCHIATRY. 2017 81:654-670 (IF: 11.982) (SCI一区)

13.Zhang N, Yang S, Wang C, Zhang J, Huo L, Cheng Y, Wang C, Jia Z, Ren L, Kang L, Zhang W. Multiple target of hAmylin on rat primary hippocampal neurons. Neuropharmacology, 2017 Feb 113(Pt A):241-251. (IF: 4.249) (SCI二区)

14.Yang J, Wang Z, Sinden DS, Wang X, Shan B, Yu X, Zhang H, Pitt GS, Wang C*. FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an sioform-specfic manner. Channels, 2016 October 10(5):410-420 (*Corresponding author, IF: 2.538) (SCI三区)

15.Zhang J, Dong M, Hu XL, Liu L, Li S, et al, Wang C*. Prostatic adenocarcinoma presenting with metastases to the testis and epididymis: A case report. Oncology Letters, 2016 11(1): 792-794 (*Corresponding author, IF: 1.664) (SCI四区)