Name: Xiaona Du

Address: Hebei Medical University

361 East Zhongshan Road 

Shijiazhuang

Hebei Province, 050017

E-mail: du_xiaona@hotmail.com

EDUCATION

PH.D. of Pharmacology, 2001-2004

Dept. of Pharmacology

Hebei Medical University

Master of Immunology, 1996-1999

Dept. of Immunology

Hebei Medical University

Bachelor of Medicine, 1991-1996

Dept. of Clinical Medicine

Hebei Medical University

EMPLOYMENT

Dean of Dept. of Pharmacology; Vice chairman of innovative drug development and evaluation centre of Health & Medicine Institute of Hebei Medical Medical University

2017.8-present

Dept. of Pharmacology, Hebei Medical University 

Professor, 2012-present;  

Dept. of Physiology, Health and Science center of University of Texas in San Antonio 

Academic scholarship, 2013.9 -2014.3

University of Leeds,UK

Academic scholarship, 2011.9-2012.1

Dept. of Pharmacology, Hebei Medical University 

Associated Professor, 2004-2011.7

The 4th Hospital of Hebei Medical University  

Resident doctor, 1999-2001

RESEARCH INTERESTS

Research interest is focused on ion channels and cell signaling, studying ion channel modulation by endogenous signaling pathway and exogenous small molecule compounds, with major interest on physiological and pathophysiological significance of ion channel modulation, especially in nervous system. Recent work focuses on peripheral sensory system, aims to unravel ion channel involvement in sensation process (such as thermoesthesia, touch and pain), to investigate ion channel related mechanism of neuropathic and inflammatory pain, to identify therapeutic targets of ion channels and develop novel ion channel modulators for pain alleviation. 

EXPERTISE

Electrophysiology

Patch-clamp

Biochemistry/Molecular Biology

DNA/RNA Isolation, PCR, Cloning, SDS-PAGE, Western blot

Cell Biology

Cell Culture, Immunofluorescence, confocal image

Bioinfomatics

Sequence Analysis, BLAST, Database Survey, Primer Design

RESEARCH SUPPORT

1.National Natural Science Foundation of China (NSFC) Research Grant 818780872. Control of peripheral nociceptive transmission and pain behavior by DRG, a new identified gate in somatosensory system. (2019.1-2022.12)

2.National Natural Science Foundation of China (NSFC) Research Grant 31571088. Local GABAergic Signaling within DRG ganglia Gates Peripheral Pain Transmission. (2016.1-2019.12) 768,000 RMB

3.Major Project for Basic Research of Hebei Science and Technology Bureau 16967712D. Primary sensory ganglia as therapeutic target of pain. (2016.1-2020.12) 300,000 RMB

4.National Natural Science Foundation of China (NSFC) Research Grant 31340048. GABAergic signaling involves the peripheral pain transmission  （2014.1-2014.12）150,000 RMB

5.National Natural Science Foundation of China (NSFC) Research Grant 30500112. “Role of Galpha subunit in specific modulation of GIRK channel  by G protein” （2006.1-2008.12）270,000 RMB

6.Natural Science Foundation of Hebei provience Research Grant C2006000826 “Distinct mechanisms of PKC inhibit Kir2.3 channel in two different expression systems” （2006.1-2008.12）40,000 RMB

ACADEMIC ACTIVITIES

2018 Organizer, speaker. The 3rd young scientist symposium of ion channel. Shijiazhuang, 2018. Apr. 15~15

2016 Organizer, speaker. Program of 2016 International Ion Channel Retreat (IICR) & Precision Medicine Frontiers. Guangzhou, 2016. Nov. 9~11 

HONOURS

2018 Extinguish Scientist in Hebei province, China 

2017 Special Scientist got governmental Allowance of Hebei Province

2012 Science and Technology Progress Award of Hebei province, second grade.

2007 Natural Science Award of Hebei province, first grade

2004 Excellent Doctor Degree Dissertation of Hebei province

TEACHING

20012-present Professor of Pharmacology, Hebei Medical Uniersity

2004-2012 Associated professor of Pharmacology, Hebei Medical Uniersity 

ORAL PRESENTATIONS

1.2019 The 7th International Ion Channels Conference. Hangzhou, June 16-20, 2019 Symposium Speaker

2.2018 The 4th Joint Meeting of Pharmacology society of Hebei, Henan and Tianjin, Kaifeng, China. 2018, Nov, 2~4 Symposium Speaker

3.2018 annual meeting of Pain Society of Hebei Medical Assocoation. Cangzhou, China. 2018, Sep, 7~9 Symposium Speaker

4.University of Leeds, UK. 2018. Aug, 7. Invited speaker.

5.The 3rd young scientist symposium of ion channel. Shijiazhuang, 2018. Apr. 14~15. Symposium Speaker

6.6th International Ion Channels Conference. Qingdao, June 23-27, 2017 Symposium Speaker

7.International Ion Channel Retreat (IICR) & Precision Medicine Frontiers. Guangzhou, 2016. Nov. 9~11. Symposium Speaker

RESEARCH PUBLICATIONS

1.Xiaona Du, Haixia Gao, David Jaffe, Hailin Zhang, Nikita Gamper* M-type K+ channels in peripheral nociceptive pathways. Br J Pharmacol. 2018, 175(12)：2158-2172. doi: 10.1111/bph.13978. （IF：6.81）

2.Xiaona Du*, Han Hao, Yuehui Yang, Sha Huang, Caixue Wang, Sylvain Gigout, Rosmaliza Ramli, Xinmeng Li, Ewa Jaworska, Ian Edwards, Jim Deuchar2,Yuchio Yanagawa, Jinlong Qi, Bingcai Guan, David B. Jaffe, Hailin Zhang*, Nikita Gamper* Local GABAergic Signaling within Sensory Ganglia Controls Peripheral Nociceptive Transmission. The Journal of Clinical Investigation, 2017 May 1; 127(5):1741-1756. doi: 10.1172/JCI86812, (IF:12.784)..

3.Xiaona Du*, Han Hao , Sylvain Gigout , Dongyang Huang , Yuehui Yang , Li Li , Caixue Wang ,Danielle Sundt , David B. Jaffe , Hailin Zhang , Nikita Gamper* . Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission. Pain. 2014 Nov; 155(11): 2306-22. (IF:5.836)

4.Du, Xiaona*; Hao, Han; Gigout, Sylvain; Huang, Dongyang; Yang, Yuehui; Qi, Jinlong; Li, Li; Wang, Caixue; Zhang, Hailin; Gamper, Nikita. Ion Channels Controlling Resting Membrane Potential of Nociceptive DRG Neuron Somata. 58th Annual Meeting of the Biophysical-Society, 2014/2/15-2014/2/19, pp 763A-764A, San Francisco, CA, 2014/1/28. 

5.Du X, Gamper N. Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Current Neuropharmacology. 2013, 11, 621-640 (IF: 2.847)

6.Yao Mi, Xuan Zhang, Fan Zhang, Jinlong Qi, Haoxia Gao, Dongyang Huang, Li Li, Hailin Zhang, Xiaona Du*. The Role of Potassium Channel Activation in Celecoxib-Induced Analgesic Action. Plos one，2013, 8(1), e54797  (IF: 4.092) 

7.Xiaona Du*, Chao Wang and Hailin Zhang*. Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats. Mol Pain. 2011 May 14; 7: 35. doi: 10.1186/1744-8069-7-35 . (IF:4.3)

8.XN Du, X Zhang, JL Qi, YM Wa, Y Fu, HX Ga, Zhaobing Gao and HL Zhang*. Characteristics and molecular basis of celecoxib modulation on Kv7 potassium channels. Brit. J. Pharmacol.2011, 164(6):1722-1737（IF:5.2）

9.Xiaona Du, Hailin Zhang, Coeli Lopes, Tooraj Mirshahi, Tibor Rohacs,and Diomedes E. Logothetis*. Characteristic interactions with PIP2 determine regulation of Kir channels by diverse modulators. The Journal of Biological Chemistry, 2004, 279(36), 37271-37281 (IF: 6.69)