Zhanfeng Jia

Ph.D., M.B.

Professor 

Dept. of Pharmacology, Hebei Medical University

PI

Center for Innovative Drug Research and Evaluation, Institute of Medical Science and Health, Hebei Medical University                 

361 Zhongshan East Road, Shijiazhuang, 050017, Hebei Province, P. R. China, 

E-mail: jiazf@hebmu.edu.cn

Work and Education Experience

2017.01-       Professor, Dept. of Pharmacology, Hebei Medical University

2011.07-2016.12 Associate Professor, Dept. of Pharmacology, Hebei Medical University

2009.07-2011.06 Lecturer, Dept. of Pharmacology, Hebei Medical University

1999.07-2003.06 Assistant Professor, Dept. of Physiology, Hebei Medical University

2011.10-2013.10 Dept. of Anesthesiology, University of Cincinnati College of Medicine, Postdoc

2006.07-2009.06 Pharmacology, Hebei Medical Univeristy, Ph.D

2003.07-2006.06 Pharmacology, Hebei Medical University, Master

1994.09-1999.06 Clinical Medicine, Hebei Medical University, Bachelor

Research interests

Molecular mechanisms of modulation of ion channels (Mechanically-activated Piezo channels KCNQ/M-type potassium channels, TRP channels, etc) and related physiological and pathophysiological significance. 

Representative Publications in Recent 5 Years

1. Zhang D, Men H, Zhang L, Gao X, Wang J, Li L, Zhu Q, Zhang H*, Jia Z*.Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice. Front Mol Neurosci. 2020, 13: 105.

2. Zhang N, Xing Y, Yu Y, Liu C, Jin B, Huo L, Kong D, Yang Z, Zhang X, Zheng R, Jia Z, Kang L, Zhang W. Influence of human amylin on the membrane stability of rat primary hippocampal neurons. Aging (Albany NY). 2020, 12 (10): 8923-8938.

3. Wang S, Geng Q, Huo L, Ma Y, Gao Y, Zhang W, Zhang H, Lv P*, Jia Z*. Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice. Front Mol Neurosci. 2019, 12: 296.

4. Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, Wang S, Gao Y, Zhang W, Zhang Y*, Jia Z*. Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle. Int J Oncol. 2019, 55 (3): 629-644.

5. Huang W, Liang J, Feng Y, Jia Z, Jiang L, Cai W, Paul C, Gu JG, Stambrook PJ, Millard RW, Zhu XL, Zhu P, Wang Y. Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte differentiation potential. Exp Cell Res. 2018, 371 (1): 20-30.

6. Zhang X, Li H, Zhang H, Liu Y, Huo L, Jia Z, Xue Y, Sun X, Zhang W. Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects. Br J Pharmacol. 2017, 174 (14): 2334-2345.

7. Sun X, Xu B, Xue Y, Li H, Zhang H, Zhang Y, Kang L, Zhang X, Zhang J, Jia Z*, Zhang X*. Characterization and structure-activity relationship of natural flavonoids as hERG K+ channel modulators. Int Immunopharmacol. 2017, 45: 187-193.

8. Zhang N, Yang S, Wang C, Zhang J, Huo L, Cheng Y, Wang C, Jia Z, Ren L, Kang L, Zhang W. Multiple target of hAmylin on rat primary hippocampal neurons. Neuropharmacology. 2017, 113: 241-251.

9. Zhang X, An H, Li J, Zhang Y, Liu Y, Jia Z, Zhang W, Chu L, Zhang H. Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect. Br J Pharmacol. 2016, 173 (24): 3480-3491.

10. Jia Z, Ikeda R, Ling J, Viatchenko-Karpinski V, Gu JG. Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons. J Biol Chem. 2016, 291 (17): 9087-9104.

11. Abd-Elsayed AA#, Ikeda R#, Jia Z#, Ling J, Zuo X, Li M, Gu JG. KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia. Mol Pain. 2015, 11: 45.

12. Ikeda R, Cha M, Ling J, Jia Z, Coyle D, Gu JG. Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulses. Cell. 2014, 157 (3): 664-675.