中文  |   English

药物化学

当前位置:首页>>师资队伍>>硕士生导师>>药物化学

刘异凡博士-副教授

发布时间:2019-10-30   浏览次数:0

调整大小 555.jpg

刘异凡,女,汉族,河北石家庄人,农工党党员。2009年本科毕业于江南大学(211)应用化学专业,2012年于大连理工大学(985)获得精细化工(应用化学)硕士学位,并获得辽宁省优秀硕士毕业生称号, 2018年毕业于韩国梨花女子大学,获得有机化学博士学位。2018年9月入职皇冠hg1088官方官网药物化学教研室任讲师,2019年11月晋升为副教授,2020年受聘为学术型和专业型硕士研究生导师,2023年被聘为河北医科大学冀医优秀学者(二层次)。社会任职:河北省科技特派员,河北省药学会药物化学专业委员会常务委员,海南省生物材料与医疗器械工程研究中心客座教授,河北医科大学第一医院硕士研究生培养合作导师。主讲课程包括《有机化学》、《化工原理》、《药物合成反应》等。

目前的科研方向为基于荧光成像和光动力治疗的小分子肿瘤诊断治疗剂的设计、合成及应用。主持的项目有:2019年河北省引进留学人员资助项目(已结题),2019年河北医科大学春雨计划优秀青年基金(已结题),2020年河北省生物医药联合基金培育项目,2021年河北省教育厅拔尖人才项目,2024年国家自然科学基金(青年项目),课题总经费83万元。目前以第一作者身份发表SCI论文17篇,其中中科院一区论文4篇。以第一发明人身份获得授权国家发明专利一项,申请中2项。

发表论文(第一作者)

1.Design of balanced dual-target inhibitors of EGFR and microtubule. Bioorganic Chemistry. 2024;143;107087. (中科院一区,IF:5.1)

2.Cardiac tropoini T (TNNT2) plays a potential oncogenic role in colorectal carcinogenesis. Cancer Cell International. 2023; 23; 146(中科院二区,IF:5.8)

3.A tyrosinase-activated Pt(II) complex for melanoma photodynamic therapy and ffuorescence imaging. Sensor Actuat B- Chem. 2023; 374; 132836. (中科院一区,IF:9.221)

4.Energy-Level Control via Molecular Planarization and Its Effect on Interfacial Charge-Transfer Processes in Dye-Sensitized Solar Cells. J Phys. Chem. C. 2019; 123; 13531-13537. (中科院二区, IF:4.309)

5.Rhodamine derivatives bearing thiourea groups serve as fluorescent probes for selective detection of ATP in mitochondria and lysosomes. Sensor Actuat B- Chem. 2019; 281: 350-358. (中科院一区, IF:6.393)

6.A new kind of rhodamine-based fluorescence turn-on probe for monitoring ATP in mitochondria. Sensor Actuat B- Chem. 2018; 265: 429-434. (中科院一区, IF:6.393)

7.Fluoride ion activated CO2 sensing using sol-gel system. Dyes and Pigments. 2017; 139: 658-663. (JCR Q2, IF:4.018)

8.Fluorescent and colorimetric chemosensors for anions, metal ions, reactive oxygen species, biothiols, and gases. B KOREAN CHEM SOC. 2016; 37: 1661-1678. (IF:0.60)

9.Pyrene based fluorescent probes for detecting endogenous zinc ions in the cells. Dyes and Pigments. 2015; 113: 372-377. (JCR Q2, IF:4.018)

10.A bispyrene derivative as a selective fluorescent probe for RNA. Chem. Comm. 2014; 50: 2505-2507. (JCR Q1, IF:6.164)

11.New iridium complexes with two pre-organized urea groups and thiourea groups as phosphorescent chemosensors for H2PO4- and chiral carboxylates. Dyes and Pigments. 2014; 100: 241-246. (JCR Q2, IF:4.018)

12.A new phosphorescent chemosensor bearing Zn-DPA sites for H2PO4-. Dyes and Pigments. 2014; 106: 20-24. (JCR Q2, IF: 4.018)

13.Visible light-harvesting perylenebisimide-fullerene (C60) dyads with bidirectional “ping-pong” energy transfer as triplet photosensitizers for  photooxidation of 1,5-dihydroxynaphthalene. Chem. Comm. 2012; 48: 3751-3753. (JCR Q1, IF: 6.164)

14.BF2-bound chromophore-containing N^N Pt(II) bisacetylide complex and its application as sensitizer for triplet-triplet annihilation based upconversion. RSC Advances. 2012; 2: 1061-1067. (JCR Q2, IF:3.049)

15.Ratiometric luminescent molecular oxygen sensors based on uni-luminophores of C^N Pt(II)(acac) complexes that show intense visible-light absorption and balanced fluorescence/ phosphorescence dual emission. Chem. Comm. 2011; 47: 11471-11473. (JCR Q1, IF: 6.164)

16.Accessing the long-lived near-IR-emissive triplet excited state in naphthalenediimide with light-harvesting diimide platinum(II) bisacetylide complex and its application for upconversion. Dalton Trans. 2011; 40: 9085-9089. (JCR Q2, IF:4.052)

17.Enantioselective recognition of tartaric acids with ethynylated carbazole-based chiral bisboronic acid chemosensors with improved response at acidic pH. J. Fluoresc. 2011; 21: 1979-1986. (JCR Q3, IF:1.913)


Baidu
sogou