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药物分析

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孔德志博士-教授

发布时间:2019-10-30   浏览次数:0

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孔德志,博士,教授、博士生导师,现任河北医科大学中西医结合研究所副所长。担任中国中西医结合学会第一届针药结合专业委员会委员、中国卒中学会新药研发与评价分会第二届委员会委员、中国药理学会补益药药理专业委员会委员、中国药理学会麻醉药理专业委员会青年委员、北京神经科学学会委员、中国药理学会神经药理专业委员会青年委员、河北省药理学会理事、河北省神经科学学会理事、《世界科学技术-中医药现代化》杂志中青年编委、国家自然科学基金项目评审专家、河北省及石家庄市项目评审专家等职。

主要从事蛋白质组学技术的方法开发及其在药物(中药)靶点发现、标志物筛选、药理作用等方面的应用基础研究。主持国家自然科学基金面上项目1项、河北省自然科学基金3项(包括重点项目1项)、河北省教育厅项目1项;参与国家科技重大新药创制专项等省部级项目7项。发表SCI科研论文40余篇,以第一或通讯作者发表中科院1区文章5篇,申请专利2项,主编新世纪创新教材1部。获得河北省教学成果二等奖1项,河北省医学科技一等奖及三等奖各1项。

代表性科研论文

1. Exploring the therapeutic potential of cannabidiol for sleep deprivation-induced hyperalgesia. Neuropharmacology. 2024:109893. (通讯作者)

2. The therapeutic effect of wine-processed Corni Fructus on chronic renal failure in rats through the interference with the LPS/IL-1-mediated inhibition of RXR function. J Ethnopharmacol. 2024;321:117511. (通讯作者)

3. Thermal proteome profiling reveals the glial toxicity of dencichine via inhibiting proteasome. Food Chem Toxicol. 2023;182:114146. (通讯作者)

4. Quantitative Proteomics Characterization of the Effect and Mechanism of Trichostatin A on the Hippocampus of Type II Diabetic Mice. Cell Mol Neurobiol. 2023. (通讯作者)

5. Revealment study on the regulation of lipid metabolism by Lingguizhugan Decoction in heart failure treatment based on integrated lipidomics and proteomics. Biomed Pharmacother. 2023;158:114066. (通讯作者)

6. Optimized approach for active peptides identification in Cerebrolysin by nanoLC-MS. Journal of Chromatography B. 2023;1225:123755. (通讯作者)

7. The mechanisms of action of mitochondrial targeting agents in cancer: inhibiting oxidative phosphorylation and inducing apoptosis. Front Pharmacol. 2023;14. (通讯作者)

8. 非修饰靶点发现细胞热位移分析技术的变革与应用进展. 药学学报. 2023:1-28. (通讯作者)

9. 神经肽功能与检测方法的研究进展. 中国药学杂志 2023;58:213-221. (通讯作者)

10.人参皂苷Rd的神经保护作用机制研究进展. 现代中药研究与实践. 2023;37:92-97. (通讯作者)

11. Essential oils: Chemical constituents, potential neuropharmacological effects and aromatherapy - A review. Pharmacological Research - Modern Chinese Medicine. 2023;6:100210. (通讯作者)

12. Improved analysis ZIC-HILIC-HCD-Orbitrap method for mapping the glycopeptide by mass spectrometry. Journal of Chromatography B. 2023;1228:123852. (通讯作者)

13. Jujuboside B inhibits febrile seizure by modulating AMPA receptor activity. J Ethnopharmacol. 2023;304:116048. (通讯作者)

14. Deficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice. Zool Res. 2022;43:851-870. (通讯作者)

15. Influence of thermal processing on the quality of hawthorn: quality markers of  heat-processed hawthorn. J Sep Sci. 2022;45:3774-3785. (通讯作者)

16. Elucidating a Complicated Enantioselective Metabolic Profile: A Study From Rats to Humans Using Optically Pure Doxazosin. Front Pharmacol. 2022;13:834897. (第一作者)

17. Classification of three types of ginseng samples based on ginsenoside profiles: appropriate data normalization improves the efficiency of multivariate analysis. Heliyon. 2022;8:e12044. (通讯作者)

18. Cell-cycle and apoptosis related and proteomics-based signaling pathways of human hepatoma Huh-7 cells treated by three currently used multi-RTK inhibitors. Front Pharmacol. 2022;13. (通讯作者)

19. Caffeic acid phenethyl ester protects against doxorubicin-induced cardiotoxicity and increases chemotherapeutic efficacy by regulating the unfolded protein response. Food Chem Toxicol. 2022;159:112770. (第一作者)

20. Screening of dual targeted inhibitors of 5-lipoxygenase and cyclooxygenase-2 from Oroxylum indicum by off-line two-dimensional liquid chromatography coupled with mass spectrometry. Ind Crops Prod. 2022;186:115243. (第一作者)

21. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell Death Dis. 2021;12:642. (通讯作者)

22. Cannabidiol inhibits febrile seizure by modulating AMPA receptor kinetics through its interaction with the N-terminal domain of GluA1/GluA2. Pharmacol Res. 2020;161:105128. (通讯作者)

23.β‐Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline‐deficient diet in mice. J Food Biochem. 2020. (通讯作者)



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