石晓伟博士-教授
发布时间:2019-10-30 浏览次数:0次
石晓伟,男,汉族,中共党员,河北乐亭人。2004年7月毕业于河北医科大学药学专业,获理学学位并留校任教至今,先后获药物化学硕士学位、药理学博士学位,历任助教、讲师、副教授、教授。现为皇冠hg1088官方官网药物化学教研室主任、教授、硕士研究生导师,主要从事《药物化学》《药物设计学》教学科研工作。河北省药学会药物化学专业委员会常务委员、药学科普专业委员会委员、中药分析委员会委员,河北省药物与卫生技术综合评估学会药品临床综合评价专业委员会委员。
主要研究方向为基于代谢的药物先导化合物发现与优化。主持河北省重点研发计划项目、河北省自然科学基金项目、河北省科技支撑计划项目、河北省高等学校科学技术研究项目等共8项,参加国家自然科学基金项目2项和河北省自然科学基金项目3项,指导本科生实验获得国家级大学生创新实验项目共2项。获省级科研成果2项,获河北省科技进步奖三等奖1项、发明专利4项。在Food Chem、Anal Bioanal Chem、J Pharm Biomed Anal、J Chromatogr B、中草药、药学学报、中国医药工业杂志等国内外权威专业期刊已发表学术论文70余篇,其中以第一作者或通讯作者发表SCI论文13篇。
主持科研项目情况:
1. 河北省自然科学基金,H2023206028,荜茇明宁碱通过亚甲二氧基苯结构代谢活化引发CYP450酶机制性失活的机制研究,2023.01-2025.12,8万元,主持人2. 河北省中医药管理局科研计划项目,2024108,强肝胶囊化学成分及药物代谢动力学研究,2024.01-2025.12,5万元,主持人
3. 河北省重点研发计划项目,20374801D,强肝胶囊质量标准提升关键技术研究与应用,2020.06-2022.12,50万元,主持人
4. 河北省自然科学基金,H2020206067,基于ADME的新型多靶点叶酸拮抗剂的成药性研究,2020.09-2022.12,10万元,主持人
5. 河北省自然科学基金,H2017206087,LC-MS精准导向发现木果楝中新柠檬苦素及其抗肺癌活性研究,2017.01-2019.12,4万元,主持人
6. 河北省高等学校科学技术研究项目,QN2017098,基于LC-MS的抗肺癌活性木果楝柠檬苦素的大鼠体内代谢研究,2017.01-2019.12,2.5万元,主持人
发表论文代表作:
1)Xiang Jiahong#, Wu Mengqi#, Wang Jianchao, Lin Mengmeng, Sun Mengmeng, Li Xin, Xing Ruijuan, Guo Ran, Gu Jianmin, Lyu Tao, Wang Lei*, Shi Xiaowei*. Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate. Frontiers in Pharmacology, 2022, 13:1001308.(中科院二区,IF=5.6)
2)Zhang Bo#, Li Xin#, Liu Yan, Tao Zifei, Xiang Jiahong, Wu Yibing, Wang Lei, Wang Qiao, Shi Xiaowei*, Han Shuang*. A UHPLC-QTOF-MS/MS method with a superimposed multiple product ion strategy and esterase inhibitor improved sensitivity for the determination of xylocarpin H in rat plasma. Journal of Pharmaceutical and Biomedical Analysis, 2022, 216:114803. (中科院三区,IF=3.4)
3)Shi Xiaowei#, Wu Yibing#, Lv Tao, Wang Yufang, Fu Yan, Sun Mengmeng, Shi Qingwen*, Huo Changhong*, Wang Qiao, Gu Yucheng. A chemometric-assisted LC-MS/MS method for the simultaneous determination of 17 limonoids from different parts of Xylocarpus granatum fruit. Analytical and Bioanalytical Chemistry, 2017, 409(19): 4669-4679. (中科院二区,IF=4.3)
4)Shi Xiaowei#, Wang Shuang#, Qian Qi, Zhou Na, Qi Pengcheng, Mu Xiyan, Wang Qiao*. Herb–herb pharmacokinetic interaction between Glehniae radix and Ophiopogonis radix in rats using superimposed multiple product ion (SMPI) LC-HR-MS/MS. RSC Advances, 2017, 7(47): 29732-29741. (中科院三区,IF=3.9)
5)Yao Donggui, Wang Yufang, Huo Changhong*, Wu Yibing, Zhang Manli, Li Ligeng, Shi Qingwen, Kiyota Hiromasa, Shi Xiaowei*. Study on the metabolites of isoalantolactone in vivo and in vitro by ultra performance liquid chromatography combined with Triple TOF mass spectrometry. Food Chemistry, 2017, 214: 328-338. (中科院一区,IF=8.8)
6)Yao Donggui, Li Zhe, Huo Changhong*, Wang Yufang, Wu Yibing, Zhang Manli, Li Ligeng, Shi Qingwen, Kiyota Hiromasa, Shi Xiaowei*. Identification of in vitro and in vivo metabolites of alantolactone by UPLC-TOF-MS/MS. Journal of Chromatography B, 2016, 1033: 250-260. (中科院三区,IF=3.0)
7)Shi Xiaowei#, Shang Weiding, Wang Shuang, Xue Na, Hao Yanxia, Wang Yabo, Sun Mengmeng, Du Yumin, Cao Deying, Zhang Kai*, Shi Qingwen*. Simultaneous quantification of naproxcinod and its active metabolite naproxen in rat plasma using LC–MS/MS: Application to a pharmacokinetic study. Journal of Chromatography B, 2015, (978-979): 157-162. (中科院三区,IF=3.0)
8)Shi Xiaowei#, Zhang Kai*, Xue Na, Su Linfei, Ma Gaixia, Qi Jinlong, Wu Yibing, Wang Qiao, Shi Qingwen*. Differentiation of genuine Inula britannica L. and substitute specimens based on the determination of 15 components using LC-MS/MS and principal components analysis. Food Chemistry, 2013, 141(4): 4019–4025. (中科院一区,IF=8.8)
9)Shi Xiaowei#, Liu Man#, Zhang Min, Zhang Kerong, Liu Songchen, Qiao Shi, Shi Rui, Jiang Xijuan, Wang Qiao*. Identification of in vitro and in vivo metabolites of isoimperatorin using liquid chromatography/mass spectrometry. Food Chemistry, 2013, 141(1): 357–365. (中科院一区,IF=8.8)
10)Shi Xiaowei#, Liu Man, Sun Mengmeng, Wang Qiao, Liu Weina, Cao Deying*. Development of a LC–ESI-MS3 method for determination of nitrendipine in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56(5): 1101-1105. (中科院三区,IF=3.4)
获奖情况
张恺,石晓伟,薛娜,李林,杜玉民,郭海波。2017年获得河北省科技进步奖三等奖,第2名。2017JB3010-2.