郭冉，女，博士，毕业于天津大学，2017年入职皇冠hg1088官方官网。博士期间的研究方向为“基于三氟重氮乙烷合成砌块构建含三氟甲基氮杂环及胺类化合物的反应研究”。2,2,2-三氟重氮乙烷作为一类高活性、多位点的三氟甲基合成砌块，在反应中既可作为C2合成子以卡宾形式参与反应也可作为1,3-偶极子参与环化反应，用于构建含三氟甲基的化合物。

以博士期间的研究为基础，目前的科研方向为新型含三氟甲基氮杂环的设计合成及其生物活性方面的研究，主持河北省教育厅基金1项、河北医科大学春雨计划优秀青年成长基金1项和河北医科大学博时启动基金1项。

目前已发表的文章：

(1) Tianfeng Gao, Congying Zhang, Xiaowei Shi, Ran Guo, Kai Zhang, Jianmin Gu, Lin Li, Shuolei Li, Qianqian Zheng, Mengyu Cui, Miao Cui, Xingmei Gao, Yi Liu, Lei Wang. Targeting Dihydrofolate Reductase : Design, Synthesis and Biological Evaluation of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolates and as Potential Antitumor Agents. European Journal of Medicinal Chemistry, 2019, 178, 329-340. (JCR 2区，SCI，IF: 4.833）。

(2) Ran Guo, Ning Lv, Fa-Guang Zhang, and Jun-An Ma. Zinc-Mediated Mannich-Type Reaction of 2,2,2-Trifluorodiazoethane with Imines: Access to β-CF3-Amines. Organic Letters, 2018, 20, 6994-6997.（JCR 1区，SCI，IF: 6.492）.

(3) Ran Guo, Yan Zheng, Jun-An Ma. Electrophilic Reaction of 2,2,2-Trifluorodiazoethane with the in Situ Generated N-Heterocyclic Carbenes: Access to N-Aminoguanidines. Organic Letters, 2016, 18, 4170?C4173. （JCR 1区，SCI，IF: 6.492）.

(4) Yi Wei, Ran Guo, Yanfeng Dang, Jing Nie, Jun-An Ma. Organocatalytic Enantioselective Decarboxylative Michael Addition of β-Keto Acids to Dicyanoolefins and Disulfonylolefins. Advanced Synthesis & Catalysis, 2016, 358, 2721-2726. （JCR 1区，SCI，IF: 5.123）

(5) Xiao-Dong Tang, Shen Li, Ran Guo, Jing Nie, Jun-An Ma. Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β-Keto Acids with 3-Hydroxy-3-indolyloxindoles. Organic Letters, 2015, 17, 1389?C1392. （JCR 1区，SCI，IF: 6.492）.

(6) Ke-Feng Zhang, Jing Nie, Ran Guo, Yan Zheng, Jun-An Ma. Chiral Phosphoric Acid-Catalyzed Asymmetric Aza-Friedel?CCrafts Reaction of Indoles with Cyclic N-Acylketimines: Enantioselective Synthesis of Trifluoromethyldihydro- quinazolines. Advanced Synthesis & Catalysis, 2013, 355, 3497-3502. （JCR 1区，SCI，IF: 5.123）.